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Effect of Rimonabant on Body Weight and the Metabolic Syndrome in Overweight Patients. 15 -- People who take the weight-loss drug rimonabant may face heightened risks for severe depression and anxiety, Danish researchers report. Acomplia (rimonabant) is the aboriginal in a new chic of ameliorative agents alleged Cannabinoid-1 Receptor Blockers (CB1). Effects Of The Cannabinoid-1 Receptor Blocker Rimonabant On Weight Reduction And Cardiovascular Risk Factors In Overweight Patients: 1-Year Experience From The RIO-Europe Study. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of rimonabant (Zimulti / Accomplia) to the US FDA. Those trials compared taking rimonabant (20 milligrams a day) against a placebo.

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