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A CB1 antagonist called rimonabant is currently marketed overseas for weight loss. Rimonabant is not yet approved for use in the United States, where it is known as Zimulti. Effects of the cannabinoid-1 receptor blocker rimonabant on weight reduction and cardiovascular risk factors in overweight patients: 1-year experience from the RIO-Europe study. Food and Drug Administration (FDA) Endocrinologic and Metabolic Drugs Advisory Committee did not recommend approval of Zimulti (rimonabant) to the US FDA for use in obese and overweight patients with associated risks factors because of continuing concerns about increased risks for suicidal thoughts among some users. Rimonabant, brand named Acomplia, is an anti-obesity drug that may help treat addiction, the team noted. Those trials compared taking rimonabant (20 milligrams a day) against a placebo.

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