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In addition, colchicine has been found to reverse abnormalities in neutrophil activity that are present in patients with Behзet's disease, i. Caution and careful attention to dosage are recommended to prevent accumulation and toxicity if colchicine is administered to these patients {05} {10}. Therapeutic doses of colchicine should be reserved for patients in whom these other agents are contraindicated or ineffective {05}. Although colchicine may retard the development of fibrosis and hepatic failure in patients with biliary cirrhosis {32} {34}, it does not relieve symptoms {04} {26} {28} {31}, prevent or reverse histological changes characteristic of the disease {04} {26} {28} {29} {31}, or decrease the need for hepatic transplantation {32}. Colchicine may also increase degradation of collagen {29}by stimulating production of collagenase {42}. Wait until the gout attack stops to begin taking Colchicine/Probenecid , unless directed otherwise by your doctor.
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